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IS (Pronounced Aiesu in Japanese) is not your everyday manga. This manga strictly deals with cases of intersexuality.
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This manga deals with issues concerning intersexual people. The pain they go through, the troubles they confront, and ultimately their inability to reproduce and even find a partner who will accept them as they are.
The series is consisted of cases, each dealing with different people - although some cases are much longer and more dramatic than others.
The series eventually ends up being about Haru, an intersex child, in a touching coming-of-age story.
Won the Kodansha Manga Award for Shoujo in 2007.
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